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    Xenovate Cream 30gm

    1 pc
    ৳140
    0
    in bag

    Product Information

    XENOVATE

    Xenovate®(Clobetasol Propionate)

    Presentation

    Xenovate ointment: Homogenous ointment; each gram ointment contains Clobetasol Propionate BP 0.5mg.

    Xenovate cream: White, smooth, water washable cream; each gram cream contains Clobetasol Propionate BP 0.5mg.

    Indications

    Xenovate (Clobetasol Propionate) ointment and cream are indicated for the topical therapy of recalcitrant corticosteroid

    responsive dermatoses, including severe cases of psoriasis (excluding widespread plaque psoriasis) and eczematous dermatitis.

    Xenovate (Clobetasol Propionate) ointment is generally chosen for dry, lichenified or scaly lesions or where a more occlusive

    effect is required.

    Xenovate (Clobetasol Propionate) cream is suitable for moist or weeping lesions.

    Dosage & administration

    Xenovate (Clobetasol Propionate) ointment and cream are applied sparingly to cover the affected area, and gently rubbed into the

    skin. Frequency of application is two to three times daily according to the severity of the condition. The total dose of

    Clobetasol Propionate cream and ointment applied should not exceed 50grams weekly. Therapy should be discontinued if no response

    is noted after a week or as soon as the lesion heals. It is advisable to use Clobetasol Propionate (Xenovate) cream and ointment

    for brief periods only.

    Contra-indications, warnings, etc.

    Contra-indications: Clobetasol Propionate ointment and cream are contraindicated in patients with hypersensitivity to Clobetasol

    Propionate. This preparation is contraindicated also in the treatment of primary infected bacterial or fungal skin lesions if no

    anti-infective agent is used simultaneously, in primary cutaneous viral infections (i.e.,herpes simplex, vaccinia and

    varicella) and in tuberculous skin lesions. Clobetasol Propionate is also contraindicated in dermatoses in children under one year

    of age, including dermatitis and diaper eruptions.

    Warnings & precautions: Clobetasol Propionate should be used with caution on lesions close to the eye. When Clobetasol Propionate

    is used over extensive areas for prolonged periods, it is possible that sufficient absorption may take place to give rise to

    adrenal suppression. This is particularly true for pediatric patients who may be more susceptible to systemic toxicity

    from equivalent doses due to their larger skin surface to body mass ratio. Topical corticosteroids may be hazardous in psoriasis

    for a number of reasons including rebound relapases, development of tolearance, risk of generalised pustular psoriasis and

    development of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis, careful patient

    supervision is important. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have

    become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of

    antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions induced by occlusive dressings, and so the

    skin should be cleansed before a fresh dressing is applied.

    Drug interaction: There has been no report of interaction with Clobetasol Propionate ointment and cream.

    Use in pregnancy & lactation: Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal

    development. The relevance of this finding to human beings has not been established. The safe use of Clobetasol Propionate during

    lactation has not been established. However, the administration of Clobetasol Propionate during pregnancy and lactation should

    only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. Drugs of this class

    should not be used extensively in pregnant patients in large amounts or for prolonged periods of time.

    Side effects: As with other topical corticosteroids, prolonged use of large amounts of Clobetasol Propionate or treatment of

    extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. This effect is more

    likely to occur in infants and children, and if occlusive dressings are used. Local atrophy may occur after prolonged

    treatment. In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the

    pustular form of the diseases Clobetasol Propionate is usually well tolerated, but if signs of hypersensitivity appear,

    application should be stopped immediately.

    Overdosage: Acute overdosage is very unlikely to occur, however, in the case of chronic overdosage or misuse, the features of

    hypercortisolism may appear and in this situation topical steroids should be discontinued gradually. However, because of the risk

    of acute adrenal suppression this should be done under medical supervision.

    Pharmaceutical precautions

    Store in a cool and dry place, protected from light.

    Packaging quantities

    Xenovate 10gm ointment : Cartons containing 10gm ointment in tube.

    Xenovate 30gm ointment : Cartons containing 30gm ointment in tube.

    Xenovate 10gm cream: Cartons containing 10gm cream in tube.

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