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    Sitagil M ER Tablet 50mg+500mg

    4 tablets
    ৳64
    0
    in bag

    PRESENTATION

    Sitagil M 50/500 ER: Each extended release tablet contains Sitagliptin Phosphate Monohydrate INN eq. to Sitagliptin 50 mg &

    Metformin HCl BP 500 mg.

    Sitagil M 50/1000 ER: Each extended release tablet contains Sitagliptin Phosphate Monohydrate INN eq. to Sitagliptin 50 mg &

    Metformin HCl BP 1000 mg.

    Sitagil M 100/1000 ER: Each extended release tablet contains Sitagliptin Phosphate Monohydrate INN eq. to Sitagliptin 100 mg &

    Metformin HCl BP 1000 mg

    DESCRIPTION

    Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which exerts its action by slowing the inactivation of incretin

    hormones. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are

    released by the intestine throughout the day and levels are increased in response to a meal. These hormones are rapidly

    inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose

    homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from

    pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from

    pancreatic alpha cells, leading to reduced hepatic glucose production. The pharmacologic mechanism of action of Metformin is

    different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases

    intestinal absorption of glucose, and increases peripheral glucose uptake and utilization.

    INDICATIONS

    Sitagliptin + Metformin ER is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as an adjunct

    to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both Sitagliptin and

    Metformin extended release is appropriate.

    DOSAGE & ADMINISTRATION

    May adjust the dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 100 mg

    Sitagliptin and 2000 mg Metformin extended release.

    Administer once daily with a meal preferably in the evening. Gradually escalate the dose to reduce the gastrointestinal side

    effects due to Metformin. Maintain the same total daily dose of Sitagliptin and Metformin when changing between Sitagliptin +

    Metformin ER, without exceeding the maximum recommended daily dose of 2000 mg Metformin extended release.

    Swallow whole. Never split, crush or chew.

    SIDE EFFECTS

    • The most common adverse reactions reported in =5% of patients simultaneously started on Sitagliptin and Metformin and more

    commonly than in patients treated with placebo were diarrhea, upper respiratory tract infection, and headache.

    • Adverse reactions reported in =5% of patients treated with Sitagliptin in combination with Sulfonylurea and Metformin and more

    commonly than in patients treated with placebo in combination with Sulfonylurea and Metformin were hypoglycemia and headache.

    • Hypoglycemia was the only adverse reaction reported in =5% of patients treated with Sitagliptin in combination with insulin and

    Metformin and more commonly than in patients treated with placebo in combination with insulin and Metformin.

    PRECAUTIONS

    Do not use the combination of Sitagliptin & Metformin in patients with hepatic disease. Before initiating the combination and at

    least annually thereafter, assess renal function and verify as normal. May need to discontinue the combination and temporarily use

    insulin during periods of stress and decreased intake of fluids and food as may occur with fever, trauma, infection or surgery.

    USE IN PREGNANCY & LACTATION

    • There are no adequate and well-controlled studies in pregnant women with Sitagliptin + Metformin ER or its individual

    components; therefore, the safety of Sitagliptin + Metformin ER in pregnant women is not known. Sitagliptin + Metformin ER should

    be used during pregnancy only if clearly needed.

    • It is not known whether Sitagliptin or Metformin are excreted in human milk. Because many drugs are excreted in human milk,

    caution should be exercised when Sitagliptin + Metformin ER is administered to a nursing woman.

    DRUG INTERACTION

    Carbonic anhydrase inhibitors should be used with caution treated with Sitagliptin + Metformin ER, as the risk of lactic acidosis

    may increase.

    Careful patient monitoring and dose adjustment of Sitagliptin + Metformin ER and/or the interfering drug is recommended in

    patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.

    OVER DOSE

    Sitagliptin

    There is no experience with doses above 800 mg in clinical studies. In the event of an overdose, it is reasonable to employ the

    usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including

    obtaining an electrocardiogram), and institute supportive therapy as indicated by the patient's clinical status.

    Prolonged hemodialysis may be considered if clinically appropriate. It is not known if Sitagliptin is dialyzable by peritoneal

    dialysis.

    Metformin Hydrochloride

    Overdose of Metformin Hydrochloride has occurred, including ingestion of amounts greater than 50 grams. Hypoglycemia was reported

    in approximately 10% of cases, but no causal association with Metformin Hydrochloride has been established. Lactic acidosis has

    been reported in approximately 32% of Metformin overdose cases. Hemodialysis may be useful for removal of accumulated drug from

    patients in whom Metformin overdose is suspected.

    COMMERCIAL PACK

    Sitagil M 50/500 ER: Each box contains 5 blister strips of 4 tablets.

    Sitagil M 50/1000 ER: Each box contains 3 blister strips of 6 tablets.

    Sitagil M 100/1000 ER: Each box contains 3 blister strips of 6 tablets

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