Pantid Tablet 40mg

Indications

Pantid is indicated where suppression of acid secretion has therapeutic benefit; i.e

Peptic ulcer diseases

Gastroesophageal reflux diseases

Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)

Eradication of Helicobacter pylori (in combination with antibiotics)

Zollinger-Ellison Syndrome

Pharmacology

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.

Dosage & Administration

Oral:

Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed.

Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.

Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.

Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.

Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment.

Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.

IV Injection:

Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days

Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days

Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours

Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour

Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

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Interaction

No significant drug interactions have been observed in clinical studies.

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

Side Effects

Pantid is well tolerated in both short-term and long-term treatment. Headache and diarrhea are the common side effects and rarely included side effects are abdominal pain, flatulence, rash, insomnia and hyperglycemia.

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. There are, however, no adequate and well-controlled studies in pregnant woman. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk. So, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

Precautions & Warnings

Patients should be cautioned that Pantid tablet should not be split, chewed or crushed. Long-term therapy of Pantid may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.

Overdose Effects

There are no known symptoms of overdosage in humans. Since Pantid is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

Direction for use of IV injection: Pantid lyophilized powder and 0.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. Pantid IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml 0.9% Sodium Chloride Injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes. Use only freshly prepared solution. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours.

Direction for use of IV infusion: Pantid IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes. Pantid IV infusion should be reconstituted with 10 ml of 0.9% Sodium Chloride Injection and further diluted (admixed) with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer's Injection to a final volume of 100 ml. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours prior to further dilution. The admixed solution may be stored at room temperature (up to 30° C) and must be used within 24 hours from the time of initial reconstitution.

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

Molecular Formula : C16H15F2N3O4S

Chemical Structure : Chemical Structure of Pantoprazole Sodium

Common Questions about Pantid 40 mg Tablet

What is Pantid 40 mg Tablet?

Pantid 40 mg Tablet is a proton pump inhibitor. It suppresses the final step in gastric acid production. It is used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome.

How long do I need to use Pantid 40 mg Tablet before I see improvement in my condition?

Pantid 40 mg Tablet is to be taken till the time you see an improvement in your health conditions.

At what frequency do I need to use Pantid 40 mg Tablet?

Pantid 40 mg Tablet should be taken in the dosage as prescribed by the doctor.

Should I use Pantid 40 mg Tablet empty stomach, before food or after food?

Pantid 40 mg Tablet should be taken prior to the meal, approximately 30 minutes before it, in the prescribed dosage.

What are the instructions for the storage and disposal of Pantid 40 mg Tablet?

Pantid 40 mg Tablet should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

What are the effects of Pantid 40 mg Tablet older adults?

Pantid 40 mg Tablet may increase the risk for bone fractures, especially with longer use, higher doses in older adults. Consult your doctor about ways to prevent bone loss/fracture.

How long does it take for Pantid 40 mg Tablet to work?

You should start to feel better within 2 to 3 days. It may take up to 4 weeks for this medication to work properly so you may still have some symptoms during this time.

Is Pantid 40 mg Tablet safe?

Yes, Pantid 40 mg Tablet is relatively safe. It is advised to consult the doctor before consuming Pantid 40 mg Tablet.

Does Pantid 40 mg Tablet cause weight gain?

In rare cases, the consumption of Pantid 40 mg Tablet can cause weight gain. You are advised to consult your doctor for any weight-related concern.

What are the side effects of Pantid 40 mg Tablet?

The side effects of Pantid 40 mg Tablet aren't that common. Still, people face the following issues sometimes - headache, diarrhea, constipation, and allergic reaction.

Can I take Pantid 40 mg Tablet if I am pregnant or breastfeeding?

Though Pantid 40 mg Tablet isn’t a serious issue for pregnant or breastfeeding person, it’s advised not to take medicine unless prescribed by your doctor.

What should I do if I miss a dose of Pantid 40 mg Tablet?

If you miss a dose of Pantid 40 mg Tablet, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time.

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