Omenix Powder 40mg

Omenix

40 capsule: Each capsule contains Omeprazole BP 40 mg as enteric Oments 20 powder for suspension Each packet contains Omeprazole BP 20 mg Omenis 40 powder for suspension Each packet contains Omeprazole DP 40 mg Omenix 40 V injection: Each vial contains Omeprazole Sodium BP as lyophilized powder equivalent to Omeprazole 40 mg

coated 23.5% pellets

capsule: Each capsule contains Omeprazole BP 20 mg as enteric coated 23.5% pellets

is a substituted benzimidazole that suppresses gastric acid secretion by specific inhibition of the gastric acid proton pump (HK ATPase enzyme) at the secretory surface of the gastric parietal cell 1 blocks the feal step of acid secretion. After oral administration, the onset of the antisecretory effect of Omeprazole occurs within one hour, with the maximum effect occurring within two hours and the duration of inhibition lasts up to 72 hours. The antisecretory effect lasts far longer than would be expected from the very short (less than one hour) plasma half-life, apparently due to prolonged binding to the parietal HK ATPase enzyme. Following absorption, Omeprazole is almost completely metabolized and rapidly eliminated mostly through urine

Omenix

Omeprazole

Presentation Omenix 20

Description Omeprazole

(both curative and maintenance therapy), Duodenal ulcer, Gastric ulcer, Reduction of nsk of upper Gl

Omenix IV is indicated primarily for the treatment of Zollinger-Ellison syndrome and may also be used for the treatment of gastric ulcer, duodenal ulcer and reflux oesophagitis

bleeding in critically ill patients

Omenix (Omeprazole) should be taken before meal. No dosage adjustment is necessary for patients with renal impairment, hepatic dysfunction or for the elderly weeks of The recommended adult oral dose is 20 mg once daily Most patients heal within four weeks. Some patients may require an additional four

Capsule & Suspension

Gastric Ulcer. The recommended adult oral dose is 40 mg once a day for 4-8 weeks. Gastroesophageal Reflux Disease (GERD): The recommended adult oral dose is 20 mg daily for up to 4 weeks. Erosive esophagitis: The recommended adult oral dose is 20 mg daily for 4 to 8 wooks.

oral starting dose is 60 mg once a day. Dosage should be adjusted to individual patient needs and should continue for as long as clinically indicated. Doses up to 120 mg Lid, have been administered. Daily dosages of greater than 80 mg should be administered in Reduction of risk of upper gastrointestinal bleeding in critically al patients. The recommended adult oral dose of Omeprazole powder for suspension is 40 mg

Zollinger-Ellison syndrome. The recommended adult

divided doses.

initially, followed by 40 mg after 6 to 8 hours as a loading dose on the first day, then 40 mg once daily for up to 14 days. The use of Omeprazole powder for suspension in critically ill patients beyond 14 days has not been evaluated. IV Injection in patients with duodenal ulcer, gastric ulcer or reflux oesophagitis where oral medication is inappropriate, Omeprazole IV 40 mg once daily is

recommended In patients with Zollinger-Ellison syndrome the recommended initial dose of Omeprazole given intravenously is 60 mg daily Higher daily doses

may be required and the dose should be adjusted individually. When doses exceed 60 mg daily, the dose should be divided and given twice daily

Impaired Renal Function Dose adjustment is not needed in patients with impaired renal function

moumdropar functions plasma half-life of Omeprazole is increased in patients with impaired hepatic function a daily dose of 10-20 mg may be sufficient

Indications and Uses

Omenix (Omeprazole) is indicated for the treatment of Heartbum, Any symptoms of GERD, Erosive esophagitis

Dosage and Administration

weeks of therapy.

kite, the simpson The mirer should

The solution for IV injection is obtained by adding 10 m waler for injection so

mast minutes at are of per minute. The action should od of 20-30 minutes or more. The cons of one it must be dissolved in -administered in the same son set with any other drug Nuson should be 100 m sine forusion or 100 ml 5% rose for infusion The so hours when dissolved in 5% dextrose The constituted aution should not

the vial After recint the injection shoul

Omeprazole well tolerated and adverse reactions have gene Den mild and reversible Scle effects may include headache, dianthosa, constipation abdominal pan nauses vomiting and flatulence, dizziness parashes somnolence, insomnia and vertige creased er eyes rash demand punts, uncan Malaise Others include hypersensitivity reactions a angioedema, fever, bronchospasm, interstitial nees and anaphylactic shock

Precautions

Sympman response to therapy with Omeprazole does not preclude the presence of gaste malignancy immediate Reinase Omeprazole formutations sodium bicarbonate which should be taken into consideration for patients on a Sodium-restricted diet

Pregnancy There are no adequate and well-controlled studies on the use of Omeprazole in pregnant women Therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk. Omeprazole should be used during pregnancy only if the potential beneta to pregnant women justifies the potential re fetus

Lactation: Omeprazole is excreted in human milk. Thus, a decision should be taken to discontinue nursing or to discontinue the drug, taking into account

Omeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation

Omeprazole can prolong the elimination of Diazepam, Wartann, Phenyloin and other vitamin K antagonists No interaction with Theophylline or Propranolol was found There have been clinical reports of interaction with other drugs metabolized via the cytochrome P-450 system eg Cyclosporine Disuram Benzodiazepines Patents should be monitored to determine if it is necessary to adjust the dosage of these drugs when taken concomitantly with Cimeprazole

Symptoms were transient, and no senous clinical outcome has been reported with Omeprazole overdose. No specific antidote for Omeprazole overdoses known Omeprazole in extensively bound with protein and is therefore, not readily dialyzable in the event of overdose, treatment should be symptomatic and

Pharmaceutical Precautions

Patients should be cautioned that the Omeprazole capsule should not be chewed or crushed and should be swatowed whole

Do not store above 30°C Keep away from light and.

Commercial Pack

Omenia 20 capsule Each box contains 10 alu-alu bister sinps of & capsules Omerix 40 capsule Each box contains 5 alu-alu blister strips of 10 capsules

Omeria 20 powder for suspension: Each box contains 30 packets

Dmenix 40 powder for suspension Each bos contains 30 packets Cimena 40 V for Injection: Each box contains wal of trophied Omeprazole 40 mg ampoule of maar for bir (10) and state disposate wyn (10)

Manufactured by

Incepta Pharmaceuticals Ltd

Savar, Dhaka, Bangladesh