Corestin Tablet 10mg

Indications

Corestin is indicated in-

Heterozygous Hypercholesterolemia (Familial and Non familial)

Homozygous Hypercholesterolemia (Familial)

Mixed Dyslipidemia (Fredrickson Type IIa and IIb)

Primary prevention of cardiovascular disease

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Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

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Administration

Rosuvastatin can be taken with or without food, at any time of day.

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Interaction

Remarkable drug interactions of Corestin are-

Cyclosporine: Combination increases Corestin exposure. Corestin dose should be limited to 5 mg once daily.

Gemfibrosil: Combination should be avoided. If used together, Corestin dose should be limited to 10 mg once daily.

Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Corestin exposure. Corestin dose should be to 10 mg once daily.

Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Corestin. INR should be monitored frequently until stable upon initiation or alteration of Corestin therapy.

Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

Contraindications

Rosuvastatin is contraindicated if-

Known hypersensitivity to product components

Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels

Pregnant women and women who may become pregnant

Nursing mothers

Side Effects

Corestin is generally well tolerated. The most frequent adverse events thought to be related to Corestin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.

Precautions & Warnings

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Corestin can be discontinued if signs or symptoms appear.

Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur.

Liver enzymes should be monitored before and during treatment

Use in Special Populations

Use in children: The safety and effectiveness in pediatric patients have not been established.

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

Storage Conditions

Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

Chemical Structure

Molecular Formula : C22H28FN3O6S

Chemical Structure : Chemical Structure of Rosuvastatin Calcium

Common Questions about Corestin 10 mg Tablet

What is Corestin 10 mg Tablet?

Corestin 10 mg Tablet is a HMG-CoA reductase inhibitor drug which is helpful in lowering the cholesterol level and triglycerides in the body.

What are the uses of Corestin 10 mg Tablet?

Corestin 10 mg Tablet is useful against the conditions like Hyperlipidemia, Hypertriglyceridemia, Type 3 Hyperlipoproteinemia and Stroke.

What are the side effects of Corestin 10 mg Tablet?

Side effects of Corestin 10 mg Tablet include Muscle pain, Weakness, Headache and Abdominal pain.

For how long should I take Corestin 10 mg Tablet?

Corestin 10 mg Tablet should be taken till you see improvement in your medical condition. Follow your doctor’s instructions to know the duration for Corestin 10 mg Tablet.

Does Corestin 10 mg Tablet cause weight gain?

Weight gain is a very rare side effect of Corestin 10 mg Tablet. This medication does not lead to weight gain and in case you are observing this symptom, please consult a doctor for diagnosis.

Does Corestin 10 mg Tablet make you tired?

Tiredness and fatigue is a common side effect of Corestin 10 mg Tablet however, the exact reason behind it is still not known. Consult a doctor if it persists for a longer duration of time.

Should Corestin 10 mg Tablet be taken at night?

Corestin 10 mg Tablet is not mandatory to take Corestin 10 mg Tablet at night. You can take it in the morning too, however, it should be consumed once a day only. Ideally, you must follow your doctor’s instructions regarding the dosage.

What foods should be avoided when taking Corestin 10 mg Tablet?

Avoid eating junk food and foods that are high in calories as they can increase the cholesterol levels. You must eat only a low-cholesterol diet during the course of Corestin 10 mg Tablet treatment.

How do I know whether Corestin 10 mg Tablet is beneficial for me or not?

If you start noticing improvement in your condition, then Corestin 10 mg Tablet is beneficial for you. In case, you do not see any positive effects of Corestin 10 mg Tablet or experience adverse side effects after consuming this medicine, then consult a doctor to know a safer substitute of Corestin 10 mg Tablet.

Can Corestin 10 mg Tablet cause memory loss?

Memory loss is a very unusual side effect that can occur. If this symptom occurs, stop taking this medicine and consult a doctor immediately.

Is it true that Corestin 10 mg Tablet can cause diabetes?

This medicine does not cause diabetes, however, if you already are at higher risk of having this disorder, then this medicine can enhance the risk factor by increasing the blood sugar levels. In such a case, regular monitoring of blood sugar level is mandatory.

Can I take alcohol with Corestin 10 mg Tablet?

Do not take alcohol during the course of treatment with this medicine as it can increase the risk of having liver problems. Also, alcohol can increase the levels of triglyceride levels in the body.

Can Corestin 10 mg Tablet cause muscle problems or muscle injury?

Muscle pain or any other problem associated with muscles is the most common side effect of this medicine. Consult your doctor if this side effect is causing discomfort in doing day to day activities.

Quick Tips

Corestin 10 mg Tablet treats high cholesterol by lowering "bad" cholesterol (LDL) and triglycerides (fats). It should be taken in addition to regular exercise and low-fat diet.

In general, Corestin 10 mg Tablet is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.

Inform your doctor if you experience fatigue, muscle weakness or muscle pain.

Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.

Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Corestin 10 mg Tablet may cause an increase in your blood sugar level.

Do not take Corestin 10 mg Tablet if you are pregnant, planning a pregnancy or breastfeeding.

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