Corangi Tablet 10mg

Product Information

CORANGI

Corangi ®Nicorandil

Presentation

Corangi- 5 tablet: each tablet contains Nicorandil INN 5 mg.

Indications

Corangi (Nicorandil) is indicated for the prevention and long-term treatment of angina pectoris.

Dosage and administration

The usual therapeutic range is 10 to 20 mg (1-2 Corangi -10 tablet/s) twice daily. The usual starting dose is 10 mg (1 Corangi –

10 tablet) twice daily, in the morning and in the evening preferably, and should be titrated upwards in accordance with patients’

needs, response and tolerance up to 40 mg twice daily, if necessary. An even lower starting dose of 5 mg (Corangi – 5 tablet)

twice daily may be used in patients particularly prone to headache. Eldery There are no special dosage requirements for elderly

patients, but as with all medicines the lowest effective dose should be used. Corangi (Nicorandil) should be administered with

care, using low starting dosages, in the elderly. Children: Not recommended. Corangi (Nicorandil) should be used with caution in

patients with serious hepatic dysfunction.

Contra-indications, warnings, etc.

Contra-indication: Nicorandil tablet is contra-indicated in patients who have shown hypersensitivity to Nicorandil. Use is

contra-indicated with cardiogenic shock and acute myocardial infarction with acute left ventricular failure and low filling

pressures, in patients with hypotension, and in patients taking phosphodiesterase-5 inhibitors because concurrent use

of Nicorandil can lead to a serious drop in blood pressure. Warnings and precautions: Nicorandil should be used with caution in

patients who may have blood volume depletion or in those who present with low systolic blood pressure (below 100 mm Hg). The use

of the drug in patients with cardiogenic shock, or acute myocardial infarction with acute left ventricular failure and low

filling pressures should be avoided. Nicorandil should be discontinued and appropriate measures taken if mouth ulceration,

stomatitis or persistent or severe buccal ulcerations, appear. Caution is advised for the use of Nicorandil in patients with

glaucoma. The hypotensive effect of other vasodilators, tricyclic antidepressants or alcohol can be increased by administration

in combination with Nicorandil. Therapeutic doses of Nicorandil may lower the blood pressure of hypertensive patients and

Nicorandil therefore, as with other antianginal agents, should be used with care when prescribed with antihypertensive drugs.

Animal mutagenicify and carcinogenicity studies have not revealed any adverse effect of Nicorandil when used under

experimental conditions.

Use in pregnancy and lactation: Although animal studies have not shown any harmful effect of Nicorandil to the foetus, has not

been studied in human pregnancy. Use in pregnant women requires that the anticipated benefit be weighed against possible hazard.

It is not known whether the drug is excreted in human milk. Caution should be exercised when Nicorandil is administered to a

nursing mother. Drug interactions: Although no pharmacological and/or pharmacokinetic interaction has been obsen/ed in animal and

human studies with Nicorandil associated with beta-blockers, calcium antagonists, digoxin, a combination of

digoxin/furosemide, rifampicin, and cimetidine, it is not excluded that the drug may nevertheless potentiate the effect of other

vasodilators, tricyclic antidepressants and antihypertensive drugs administered concurrently, especially in combination with

alcohol.

Adverse reaction: Headache (especially on initiation, usually transitory); cutaneous vasodilation with flushing; nausea, vomiting,

dizziness, weakness also reported; rarely oral ulceration and myalgia; at high dosage, reduction in blood pressure and/or increase

in heart rate; angioedema, also reported.

Overdosage: ln the case of overdosage, the likely symptomatology may be peripheral vasodilation with a fall in blood pressure and

reflex tachycardia. In such an event, monitoring of cardiac function and general supportive measures should be used. If not

successful, circulating plasma volume should be increased by substitution of fluid. ln life-threatening situations, administration

of vasopressors should be considered.

Pharmaceutical precautions

Store in a cool and dry place, protected from light.

Packaging quantities

Corangi- 5 tablet: Cartons of 10/20/30/so tablets in alu-alu blister.