Contine Tablet 200mg

Presentation:

Contine Tablet : Each controlled release tablet contains Theophylline USP 400 mg.

Contine-200 Tablet: Each controlled release tablet contains Theophylline USP 200 mg.

Contine-300 Tablet: Each controlled release tablet contains Theophylline USP 300 mg.

Contine Syrup: Each 5 ml syrup contains Theophylline Sodium Glycinate USP 120 mg equivalent to Anhydrous Theophylline 55 mg.

Indications:

Contine is indicated for the prevention & treatment of symptoms of asthma and reversible bronchospasm associated with chronic

bronchitis and emphysema.

Dosage & Administration:

Dosages are adjusted to maintain serum theophylline concentrations that provide optimal relief of symptoms with minimal side

effects. Most of the controlled release preparations may be administered every 12 hours in adults while administration every 8

hours may be necessary in some children with markedly rapid hepatic metabolism of theophylline. The recommended dosages for

achieving serum theophylline concentrations within the accepted therapeutic range is as follow:

Age

Dose (mg/Kg/day)

1-6 months

10

6 months-1 year

15

1-9 years

24

10-l6 years

18

Adults

10-15

Contrainidications:

Theophylline is contraindicated in individuals who have shown hypersensitivity to its components.

Side effects:

The following side effects have been observed:

Gastro-intestinal: Nausea, vomiting, epigastric pain and diarrhoea.

Central nervous system: Headache, irritability, restlessness, insomnia, muscles twitching.

Cardiovascular: Palpitation, tachycardia, hypotension. circulatory failure.

Respiratory: Tachypnoea.

Renal: Potentiation of diuresis.

Others: Alopecia, hyperglycemia, rash etc.

Drug interaction:

Allopurinol, Cimetidine, Ciprofloxacin. Erythromycin, Lithium carbonate, Oral contraceptive, Propranolol increases serum

theophylline level when administered concomitantly and Rifampicin decreases serum theophylline level.

Use in special groups:

Theophylline should not be administered concurrently with other xanthine. Use with caution in patients with hypoxemia,

hypertension, or those with history of peptic ulcer. Do not attempt to maintain any dose that is not tolerated.

Use in Pregnancy:

It is also not known whether theophylline can cause fetal harm when administered to a pregnant woman or can affect reproduction

capacity. Xanthine should be given to a pregnant woman only if clearly needed.

Use in Nursing Mothers:

Theophylline is excreted into breast milk and may cause irritability or other signs of toxicity in nursing infants. Theophylline

should be given to nursing mother only if clearly needed.

Packing:

Contine Tablet: Each box contains 100’s tablets in blister pack.

Contine-200 Tablet : Each box contains l00’s tablets in blister pack.

Contine-300 Tablet : Each box contains 100’s tablets in blister pack.

Contine Syrup : Each bottle contains 100 ml syrup.