Bukof Tablet 50mg

Bukof

Butamirate Citrate

film coated tablet

Composition

Bukof Tablet: Each sustained release contains Butamirate Citrate INN 50 mg

Bukol Kids Paediatric Drops: Each mL paediatric drops contains Butamirate Citrate INN 5 mg.

7.5 mg.

Bukof Syrup: Each 5 ml syrup contains Butamirate Citrate INN Bukof-D Syrup (Sugar Free): Each 5 mL syrup contains Butamirate Citrate INN 7.5 mg.

Pharmacology

Bukof is centrally acting cough suppressant which is neither chemically nor pharmacologically related to opium alkaloids. In addition to its antitussive effect, Bukof" also decreases the airway resistance. Bukof" is rapidly and completely absorbed after oral administration. Maximum concentration is reached within 9 hours. Bukof" is extremely protein bound and Plasma elimination half-life is about 13 hours.

Indication

Bukof is indicated in acute cough of any etiology, pre and post operative cough sedation for surgical procedure and bronchoscopy.

Dosage and Administration

Bukof Tablet

12 years age: 1 to 2 tablets daily

Adolescents over

Adults

: 2 to 3 tablets daily at 8 to 12 hours intervals.

Bukof Kids Paediatric Drops

Children (2 months-1 year) : 0.50 mL (10 drops) 4 times daily.

Children (1-3 years)

: 0.75 mL (15 drops) 4 times daily.

Bukof 100 mL syrup Children 3 to 6 years of age : 5 mL syrup 3 times daily

6 to 12 years

Adolescents over 12 years ago:

Adults

Bukof-D 100 mL syrup Children 3 to 6 years of age

:10 mL syrup 3 times daily 15 mL syrup 3 times daily

:15 mL syrup 4 times daily

6 to 12 years Adolescents over 12 years age 15 mL syrup 3 times daily Adults

5 mL syrup 3 times daily 10 mL syrup 3 times daily

Contraindication

Hypersensitivity to the active ingredient,

: 15 mL syrup 4 times daily

Warning & precaution

Due to inhibition of the cough reflex by Butamirate Citrate, the

simultaneous administration of expectorants has to be avoided.

Locates a may to stagnation of rousius in which increases the risk of bronchospasm and airways infection

A doctor or pharmacist needs to be consulted if the cough persists for more than 7 days

Side effects Bukof" is well tolerated in rare cases, skin rash, nausea, diarrhea,

dizziness have been reported. They disappear after reduction of the dosage or discontinuation of the drug The use of Bukot should be avoided during the first three months of

Use in pregnancy and lactation

pregnancy. During the rest of pregnancy, Bukof" should be used only it drug therapy is essential. For safety reasons, as a general rule, the benefits and risks of taking Bukof" during lactation should be carefully considered.

Use in children and adolescents

Bukof" Kids can be given to 2 months children. Bukof" can be given to 3 years children and it is safe for adolescents.

Drug interaction

Concomitant use of expectorants may lead to retention of mucous in the respiratory system, which can increase the risk of bronchospasm and airway infection.

Overdosage Overdose may cause nausea, vomiting, diarrhea, dizziness and

hypotension. The usual emergency assistance should be taken:

activated charcoal, saline laxative and symptomatic treatment should

be given.

PHARMACEUTICAL INFORMATION:

Storage

Store in a cool (below 30°C temperature) and dry place, away from light. Keep out of the reach of children.

Packing

Bukof Tablet: Each commercial box contains 30 tablets

Alu-Alu blister pack.

in

Bukof Kids Paediatric Drops: Each commercial box contains a

HDPE bottle containing 15 mL Paediatric Drops and a measuring dropper. Bukof Syrup: Each commercial box contains a PET bottle containing 100 ml syrup and a measuring cup.

Bukof-D Syrup: Each commercial box contains a PET bottle containing 100 mL syrup and a measuring cup.

Manufactured By

BEACON Pharmaceuticals Limited

Bhaluka, Mymensingh,Bangladesh.