Bopam Tablet 3mg
10 tabletsBopam
Bromazepam be
Description
Bromazepam (Dopam") is a global anxiolytic with smooth and superior efficacy it is one of the benzodiazepines having no side-effects like other benzodiazepines. It effectively manages anxiety and also removes anxiety related various physiological problems
Mode of action
Bromazepam (Bopam") binds with the specific site on the GABA receptor/chloride channel complex and potentiates the effect of GABA, an important inhibitory transmitter in the CNS which acts by opening chloride ion channels into cells.
Pharmacokinetics
Peak plasma concentration of Bromazepam (Bopam") is achieved within two hours after oral administration. The absolute bioavailability of the unchanged substance is 60%. On an average 70% of Bromazepam is bound to plasma proteins. Bromazepam is metabolized in the liver. Bromazepam has an elimination half-life of around 20 hours, but the half-life may be longer in elderly subjects. The metabolites are excreted in the urine mainly in conjugated form..
Composition
Bopam Tablet: Each tablet contains Bromazepam BP 3 mg
Indications
Emotional disturbances: Anxiety and tension states, as adjuvant therapy for anxiety in depressed patients, nervous tension, restlessness, anxiety and tension related insomnia. As an adjuvant to the treatment of an underlying disease responsible for functional or psychosomatic impairments of various organs caused or exacerbated by anxiety and tension. Cardiovascular and respiratory systems: Pseudo angina pectoris, precordial anxiety, tachycardia, emotiogenic hypertension. dyspnea and hyperventilation; Gastrointestinal tract: Irritable bowel syndrome, ulcerative colitis, epigastric pain, spasm, meteorism and diarrhea. Urogenital tract: Irritable bladder, urinary frequency. dysmenorrhoea; Other psychosomatic disturbances: Psychogenic headache, psychogenic dermatoses.
Bromazepam is also suitable for treatment of anxiety and tension states due to chronic organic diseases and as an adjuvant to psychotherapy in psychoneuroses, acute alcohol withdrawal, adjunct for the relief of muscle spasm.
Dosage & administration For adult 1.5 mg to 12 mg three times daily according to condition or
patient response and side-effect profile.
Average outpatient dosage: 1.5 mg to 3 mg three times daily. Severe cases: 6 mg to 12 mg two to three times daily.
Contraindications Bromazepam
should not be used in case of hypersensitivity of benzodiazepines, respiratory depression, severe hepatic impairment. myasthenia gravis and infant.
Side effects
Drowsiness, lightheadedness in the next day: confusion, ataxia and amnesia may occur.
Use in pregnancy & lactation
USFDA pregnancy category C. Bromazepam should avoid during lactation because this molecule excreted through breast milk.
Precautions Bromazepam should be used cautiously in respiratory diseases, muscle weakness, and history of alcohol or drug abuse,
Drug interactions
Phenothiazines, barbiturates, MAO inhibitors and psychoactive drugs may potentiate the action of bromazepam and should not usually be
given concurrently.
Overdosage
Manifestations of overdosage include somnolence, confusion,
and
respiratory and cardiovascular depression with coma in severe cases.
Storage
Store in a cool and dry place, protected from light.
Packaging Bopam Tablet: Each carton contains 10X5 tablets in blister pack.
Manufactured by
Opsonin Pharma Limited Rupalali, Barishal, Bangladesh. Registered Trade Mark.