Axicef Plus Tablet 500mg+125mg

Indications

Axicef Plus is indicated for the treatment of infections caused by sensitive bacteria.

Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.

Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes.

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Pharmacology

Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.

Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.

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Dosage & Administration

Adolescents and adults (13 years and older)-

Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days

Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days

Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days

Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days

Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days

Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days

Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose

Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days

MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days

Early Lyme disease: 500 mg b.i.d. for 20 days

Paediatric Patients (3 months to 12 years)-

Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days

Acute otitis media: 30 mg/kg/day b.i.d for 10 days

Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days

Impetigo: 30 mg/kg/day b.i.d for 10 days

Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.

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Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

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Contraindications

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Side Effects

Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Pregnancy & Lactation

While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.

Common Questions about Axicef Plus 500 mg Tablet

What is Axicef Plus 500 mg Tablet?

Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Axicef Plus 500 mg Tablet is indicated for the treatment of infections caused by sensitive bacteria.

What is Axicef Plus 500 mg Tablet used for?

Axicef Plus 500 mg Tablet is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.

How long does it take for Axicef Plus 500 mg Tablet to take effect?

Axicef Plus 500 mg Tablet starts working within 2-3 hours after taking it.

How long do the effects of this medicine last?

The effect of Axicef Plus 500 mg Tablet lasts for an average duration of 4-8 hours.

Axicef Plus 500 mg Tablet it safe to consume alcohol while taking this medicine?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is Axicef Plus 500 mg Tablet a habit forming medicine?

No habit-forming tendencies were reported for Axicef Plus 500 mg Tablet.

Can this medicine be taken during pregnancy?

Axicef Plus 500 mg Tablet is safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.

Can Axicef Plus 500 mg Tablet be taken while breast-feeding?

Axicef Plus 500 mg Tablet is safe to use during breastfeeding. It enters into breast milk at low levels.

Quick Tips

You have been prescribed Axicef Plus 500 mg Tablet medicine to treat bacterial infections, even if they have developed resistance.

Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.

Take it with food to avoid an upset stomach.

Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.

Stop taking Axicef Plus 500 mg Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

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