Aprodex 5 ml Eye Drops
eachIndications of Aprodex 5 ml Ophthalmic Solution
Eye: This combined eye drop is used to treat steroid-responsive inflammatory ocular diseases in which bacterial infections or the danger of bacterial infections are present. When there is a high risk of infection or an anticipation that potentially hazardous quantities of bacteria would be present in the eye, a combination medication including an anti-infective component is recommended. The combination can also be utilized to treat post-operative inflammation as well as any other infection-related ocular inflammation.
It's used to treat ear infections that are accompanied by inflammation, such as otitis externa, otitis media, and chronic suppurative otitis media. The combination can also be used to treat ear irritation after surgery.
Pharmacology of Aprodex 5 ml Ophthalmic Solution
The glucocorticoid dexamethasone is. It works as an anti-inflammatory and anti-allergen. It's used topically to the eye's anterior region to treat inflammatory disorders. By inhibiting the enzyme phospholipase A2, it lowers prostaglandin production. Dexamethasone also prevents neutrophils from chemotactically infiltrating the inflammatory area.
Ciprofloxacin has the highest antibacterial activity of all quinolones in vitro against a wide spectrum of gram-negative and gram-positive bacteria. Ciprofloxacin's bactericidal effect is due to interference with the enzyme DNA gyrase, which is required for bacterial DNA synthesis.
Dosage & Administration of Aprodex 5 ml Ophthalmic Solution
For Eye: 1 drop to be instilled into conjunctival sac(s) every four to six hours. During the initial 24 to 48 hours, the dosage may be increased to 1 drop every two hours.
For Ear:
Acute otitis media in pediatric patients with typanastomy tube: 4 drops instilled into the affected ear 2 times daily for 7 days.
Acute otitis externa: 4 drops instilled into the affected ear 2 times daily for 7 days.
Frequency should be decreased gradually or warranted in clinical signs. Care should be taken not to discontinue therapy prematurely.
Interaction of Aprodex 5 ml Ophthalmic Solution
Specific drug interaction studies have not been conducted with ophthalmic Ciprofloxacin and Dexamethasone. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant warfarin and its derivatives and have been associated with transient elevations in serum creatinine in patients receiving cyclosporin concomitantly.
Contraindications
Known hypersensitivity to any ingredient of the product. Herpes simplex and other viral conditions, mycosis, glaucoma, newborn babies, fungal diseases of ocular or auricular structures.
Side Effect of Aprodex 5 ml Ophthalmic Solution
Transient eye burning or pain is a common side effect reported by patients. Stinging, redness, itching, photophobia, conjunctivitis/ keratitis, periocular/ facial edema, foreign body feeling, impaired vision, tears, dryness, and eye discomfort are among the other side effects described. IOP elevation and delayed wound healing are uncommon complications associated with the development of glaucoma.
Pregnancy & Lactation
Use during pregnancy: Only if the possible benefit outweighs the danger to the fetus should this be used during pregnancy.
Use in lactation: It's unclear if topical corticosteroids would result in enough systemic absorption to generate measurable amounts in human milk. It's also unclear if ciprofloxacin is excreted in human milk after topical use. Because many medications are excreted in human milk, care should be used when giving the combination to a nursing mother.
Precautions & Warnings
In ocular hypertension and/or glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior sub capsular cataract formation, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi; in ocular hypertension and/or glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior sub capsular cataract formation. Patients who utilize contact lenses should not use the drops while wearing the lenses.
Therapeutic Class
Aural steroid & antibiotic combined preparations
Storage Conditions
Store away from light in a cool, dry area. Keep out of children's reach. Before each usage, give it a good shake.